Objectives: Total Knee Replacement (TKR) is a common orthopaedic surgical procedure executed to relieve pain and restore function in patients with severe knee joint pain. However, Notable postoperative pain is predominately experienced after surgery and that may interfere with early functional recovery. Effective pain control strategies are required to improve patient recovery and clinical outcomes. The combination of Tramadol and Acetaminophen is widely used as part of the therapy for pain management. This research aims to evaluate the effectiveness of tramadol and acetaminophen in reducing postoperative pain in patients undergoing total knee replacement surgery and to assess variations in pain reduction among patients using different factors.

Methodology: Prospective observational study in orthopaedic department at tertiary care hospital for 6 months is done. Subjects with osteoarthritis (OA) who underwent TKR will have their pain score recorded. To be eligible for inclusion, patients must satisfy the following requirements: they must be above 50 years old, have a confirmed diagnosis of OA and have access to their medication chart. The goal of this study is to conduct a focused investigation on pain management after combinational therapy by excluding pt’s under 50 years, individuals with cancer and pregnancy. Age, gender, comorbidities, length of illness, and medication usage are some of the demographic details that will be collected. Postoperative pain was assessed using the Numeric Rating Scale (NRS) and Visual Analog Scale (VAS) for the consecutive days following surgery. Patients received a combination therapy of tramadol and acetaminophen as part of the postoperative analgesic regimen. Pain scores were recorded daily and analysed to determine the trend of pain reduction. Additional observations were made to compare the relation between pain reductions with respect to other factors among every patient.

Results: A non-random purposive selecting strategy was used to choose 62 patients in total for the investigation. The results showed a gradual reduction in pain scores over the consecutive postoperative period in most patients receiving tramadol and acetaminophen. Pain levels were highest on the first postoperative day and progressively decreased in further days. However, a comparatively slower reduction in pain scores was observed in patients with comorbid patients, suggesting that these groups may experience delayed pain relief due to factors such as impaired healing, altered pain perception, and comorbid conditions.

Conclusion: From the obtained data we analysed that affected individuals are more females (61%). The combination of Tramadol (TRA) and Acetaminophen (APAP) was found to be an effective strategy for postoperative pain management, demonstrating a steady reduction in pain scores over the days. However, comorbid patients showed delayed pain reduction.