Background: One of the most prevalent causes of pain, limited mobility, and a lower quality of life in adults is musculoskeletal and joint pain problems topical analgesics are participants first choice, as onset of action is quick and safe even when applied multiple times.

Methods: Thirty participants with acute or chronic musculoskeletal and joint pain disorders were randomized in an open-label, comparative clinical study design and were assigned to two groups where one group received test product which contained 6 % cannabis extract and other group received standard comparator gel. The onset of pain relief, complete pain relief was observed for 120 minutes post application, Visual Analog Scale (VAS) and Numerical Pain Rating Scale were used to measure the intensity of pain at rest and during movement. The Short Form 12 (SF 12) questionnaire was used to assess quality of life. Subject safety was assessed by pre and post systemic lab parameters in addition to adverse event monitoring.

Result: Pain Relief Gel with 6% Cannabis Extract demonstrated onset of pain relief, cooling/tingling/burning sensation and complete relief of pain at 2.67 ±1.49 minutes, 48.67±10.93 seconds and 66.07±36.05 minutes respectively, comparable to the standard comparator gel. Duration of action in Pain Relief Gel with 6% Cannabis Extract was 7.6±6.9 hours. Pain intensity measured at different timepoints related questioners were statistically significant in both the groups.