Background: Acute musculoskeletal and joint injuries commonly cause pain, restricted movement, and functional disability, significantly affecting quality of life. While multiple treatment modalities exist, topical oil-based formulations provide a convenient, cost-effective option with rapid onset of action and minimal systemic adverse effects.

Method: This randomized, open-label, comparative clinical study included 30 participants with musculoskeletal and joint pain disorders, who were randomized to receive either Pain Relief Oil with 6% Cannabis Extract or Dr. Ortho Oil (n=15 each) and applied topically twice daily for two weeks. Efficacy of the test product was assessed using pain intensity scales, onset and duration of pain relief, functional outcomes, patient satisfaction, quality of life measures, and inflammatory markers, while safety was evaluated through monitoring adverse events.