Background and Aims: Chronic neck pain with or without radicular pain due to nerve root inflammation is prevalent in the adult population, causing significant functional limitations. Epidural steroid injections (ESI) have been used effectively to reduce inflammation and provide pain relief. This study aimed to assess the efficacy and safety of ESI in patients with chronic cervical pain refractory to non-steroidal anti-inflammatory drugs (NSAIDs).

Methods: This prospective study included 40 patients aged 36–54 years with a mean symptom duration of eight months, conducted at a tertiary care center. Patients received fluoroscopy-guided ESI consisting of Methylprednisolone (80 mg), Hyaluronidase (1,500 IU), Lignocaine Hydrochloride (2%), and Normal Saline (total volume: 10 ml). Pain relief and functional recovery were assessed using the Verbal Rating Scale (VRS) over follow-ups at three days, two weeks, two months, and six months.

Results: All patients reported complete pain relief at three days and two weeks, with mild injection site pain in four cases. At two months, 87.5% had complete relief, 5% reported 75% relief, and 2.5% experienced 50% relief, while 5% reported pain similar or worse than before ESI. At six months, 75% maintained complete relief, 7.5% had 50% relief, and 17.5% reported worsening pain. No major immediate or late complications were observed.