Global health burden of disease and musculoskeletal disorders were reported to be the second leading cause of disability worldwide. This suggests that many people are affected with musculoskeletal disorders worldwide imposing huge financial cost in treatment and management of musculoskeletal disorders among patients globally. Consequently the need arises for the study on the socio-demographic variables associated with prevalence of common musculoskeletal disorders among rheumatology patients in Imo State with respect to age and gender of the patients. Three research questions and three hypotheses guided the study. The study adopted ex-post facto research design. It was carried out in Imo State. Population of this study consisted of all the 17,787 patients both old and young who were screened for musculoskeletal disorders in the hospitals that offer services on musculoskeletal disorders in Imo State from 2016-2020 based on census sampling. The instrument for data collection for this study was valid folders of the patients (a proforma). Data collected were analyzed using descriptive statistics of frequency count and percentages to answer the research questions while inferential statistics of chi-square was used to test the hypotheses at p < 0.05. The results revealed that demographic variables (such as year, age and gender) associated significantly with the level of prevalence of common musculoskeletal disorders among inhabitants in Imo State. Based on the findings of the study, it was concluded age and gender have effects on prevalence of common musculoskeletal disorders patients. It was recommended among others that the government should plan a gender and age specific enlightenment programmes for the most at risk group of common musculoskeletal disorders.