Background: Chronic musculoskeletal pain disorders (CMPDs) are among the leading causes of disabilities across populations, resulting in high social and financial burden. This persistent pain condition may include the central sensitization (CS) phenomenon, which implies a wide range of symptoms and that may be taken into account in CMPD treatment. CS symptoms can be measured by the Central Sensitization Inventory (CSI). Objective: The aims of the study were to know the frequency of CS symptoms in patients suffering from different CMPDs. Methods: In present cross-sectional study total of 185 gujarati participants aged 18-75, suffering from several CMPDs were included. CS symptoms were measured with the Gujarati Version of the CSI. The Demographic Data and CSI Score were analyzed by mean, median and standard deviation. The level of significance was set at α = 0.05. Results: The mean CSI total score for the whole sample was 24.73±15.28 points. CSI total score had subclinical values in the whole sample, whereas participants with scores ≥40 were found across different CMPDs, such as low back pain (36.73%) and neck pain (31.71%); 28.44% of females and 10.53% of males presented CSI scores ≥40. Patients showed significant differences in CSI total score by gender (P = 0.096). Conclusion: Present study conclude that although participants showed mean subclinical values in CSI total score, participants with scores ≥40 were found across different CMPDs, ages, BMI and duration subgroups. In particular, females, LBP and neck pain participants were the subgroups most affected by high CSI scores.