Background: Osteoarthritis (OA) is a disease where Hyaluronic acid in the knee joints has broken down making them painful and difficult to move. Material and Methods: 40 patients were taken with various grades of osteoarthritis of the knee. Three times Intra articular injection was given at an interval of two weeks. Patients were reviewed at six weeks and three months interval. Results: 85% of the patients had decreased knee pain following the injection. 17 patients did not require any adjunctive therapy. 10 patients showed no improvement at all and were advised replacement surgery for the knee. However for 11 patients oral corticosteroids and analgesics were given. One of the patient had knee infection following the injection. One patient could not be contacted for follow up. Grade 1 and 2 osteoarthritis knee patients showed better results as compared to grade 3 and 4. Conclusion: Intra articular sodium hyaluronate is a good, easy and safe method for treatment of knee osteoarthritis.