International Journal of Orthopaedics Research

International Journal of Orthopaedics Research


International Journal of Orthopaedics Research
International Journal of Orthopaedics Research
Vol. 2, Issue 4 (2020)

A comparative study of reduction of blood loss after use of tranexamic acid intravenous versus topical in unilateral total hip replacement: A prospective study


Sumit Saini, Ashish Chopra

Total hip Replacement (THR) is one of the most widely performed elective orthopaedic surgery. THR is a successful procedure but it has it's own complications. Some complications that have been seen in THR are blood loss, infection, dislocation, thromboembolism, neurovascular injuries, limb length discrepancy & implant failure. Current research in THR is targeted at reducing post-operative complications including blood loss and improving the design to improvise patient function. Many interventions have been developed to reduce intraoperative and post-operative blood loss. The use of tranexamic acid in primary THR is widely accepted today and several studies have confirmed its efficacy for decreasing blood loss without any significant increase in complications. The efficacy and safety of topical versus IV tranexamic acid often differs and more studies are required to validate the results. Our study aimed to compare reduction of blood loss after use of tranexamic acid intravenous versus topical in unilateral total hip replacement. Materials & Methods: The study comprised of 82 patients scheduled for primary THR. Tranexamic acid was given locally in 41 patients and intravenously in another 41 patients. Blood samples were collected from all the subjects on post-operative day 1 & 3. Blood loss was calculated using standard parameters & Good et al 2003 equation. Results: In our study, the amount of blood loss was found to be lower in IV group as compared to the local group. In group A (topical), amount of the blood loss ranged from 224.4 - 1834.5 ml amongst the subjects, with a mean (± SD) of 828 ± 406.6 ml. Whereas, in group B (intravenous) the amount of blood loss varied from 172.3 - 937.2 ml with a mean (± SD) of 598.3 ± 207.5 ml. When analyzed, there was a statistically significant difference between the groups (p = 0.001). Conclusion: Our study concluded that the amount of blood loss in THR to be lower in IV group as compared to the local group.
Download  |  Pages : 04-07
How to cite this article:
Sumit Saini, Ashish Chopra. A comparative study of reduction of blood loss after use of tranexamic acid intravenous versus topical in unilateral total hip replacement: A prospective study. International Journal of Orthopaedics Research, Volume 2, Issue 4, 2020, Pages 04-07
International Journal of Orthopaedics Research International Journal of Orthopaedics Research