Purpose: Prostate cancer is common cancer in men in the world, Bone metastases and skeletal-related events are major causes of morbidity. This study reveals the incidence of bone metastases and the most frequent sites secondary to prostate cancer in Khartoum oncology hospital. Method: A Retrospective study in Khartoum oncology hospital September 2019 to March 2020. Demographic and clinical information extracted from the medical records of eligible patients in the last 5 years 2015-2019 included age, sex, social habits, duration of prostate cancer, duration of treatment, and location of bone metastasis. Statistical analyses were performed using SPSS, Version 22.0. Results: From all patients diagnosed with prostate cancer, 12.25% had developed bone metastasis out 52.4% of whom of patients developed bone metastasis in 2-5 years of diagnosis of prostate cancer and 40% in less than 2 years of diagnosis. lumbar vertebrae (56.9%) is the most common site of bone metastasis followed by pelvis (50.5%), Lumbar vertebrae L4 and L5 tended to be more commonly affected (35.8%, 34% respectively). Skeletal-related events in 70 patients (63.3%), involved bone fracture in 1.8%, bone pain in 58.56%, hypercalcemia in 9%, and other spinal cord compression manifestation in 25.2%. Conclusions: The most common site of bone metastasis in prostate cancer is lumbar vertebrae, the duration of prostate cancer affects the development of bone metastasis, exploring the knowledge of patient populations prone to develop bone metastasis and skeletal-related events helps in further intervention and management.