Introduction: Cervical spondylitis is a degenerative condition affecting the cervical spine and is a common cause of neck pain and disability in adults. Inflammatory serum biomarkers, including tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), interleukin-1 beta (IL-1β), C-reactive protein (CRP), and erythrocyte sedimentation rate (ESR), have been implicated in various inflammatory conditions. This study aimed to investigate the role of these inflammatory serum biomarkers in the pathogenesis of cervical spondylitis.

Material and Methods: A cross-sectional study design was employed, recruiting 100 participants diagnosed with cervical spondylitis from a tertiary medical center. Serum levels of TNF-α, IL-6, IL-1β, CRP, and ESR were measured using validated laboratory techniques. Demographic characteristics, clinical features, and medical history of the participants were also collected. Statistical analyses were performed to assess the association between serum biomarker levels and cervical spondylitis.

Results: The mean serum levels of TNF-α, IL-6, IL-1β, CRP, and ESR in the study participants were 46.09 pg/mL, 16.49 pg/mL, 6.62 pg/mL, 6.88 mg/L, and 23.2 mm/hr, respectively. These values indicated a low-grade systemic inflammation in individuals with cervical spondylitis. Participants with comorbidities, such as obesity, diabetes mellitus, hypertension, and osteoarthritis, showed potentially influenced biomarker levels.