Objective:Different strategies have been developed to reduce blood loss in total knee arthroplasty (tKA). The efficacy of both systemic and local tranexamic acid (tXA) administration is demonstrated in the literature. The aim of the present study was to assess the efficacy of local tranexamic acid in reducing blood loss and requirement of blood transfusion in total knee replacement. Methods:The retrospective study was conducted at our super speciality Hospital and comprised data of patients who underwent total knee replacement between January 2018 and December 2018. The effect of intra articular tranexamic acid on postoperative haemoglobin and number of blood units transfused was noted. Results:A total of 100 patients undergoing knee replacement surgeries were selected with 20(20%) men and 80(80%) women. The overall mean age was 62 years (range: 42-86 years). Local Tranexamic acid was used in all the patients. When it was used, only 2 (2%) patients required blood transfusion. the average fall in haemoglobin postoperatively was 0.872 gm/dl. Conclusion: Intra articular Tranexamic acid was able to reduce total blood loss and transfusion requirements